2-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepine → HCID 19985830, compound

HRID 974331Notes

Reaction equation

HRID 974331 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][CH2:10][CH2:11]CS([O-])(=O)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:17][C:18]1[S:19][C:20]2[CH2:21][CH2:22][NH:23][CH2:24][CH2:25][C:26]=2[N:27]=1>C(Cl)(Cl)Cl>[NH2:17][C:18]1[S:19][C:20]2[CH2:21][CH2:22][N:23]([CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH2:24][CH2:25][C:26]=2[N:27]=1

Participants

4

Reactant 2

HCID 199857852-Amino-4,5,6,7,8-pentahydrothiazolo[5,4-d]azepineHCID 20496925HCID 20496925, compound

Product 1

HCID 19985830HCID 19985830, compoundYield 19%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Prepared from 5-phenyl-1-pentyl-mesylate and 2 equivalents of 2-amino-4,5,7,8-tetrahydro-6H- thiazolo[5,4-d]azepine in chloroform. Yield: 19% of theory, Melting point: 102°-105° C. (petroleum ether).

Sources & evidence

ORD record
ord-891d779904fd49d0b86753a5040c6c9c
Source dataset
uspto-grants-1991_11
Patent number
US05068325

Reaction notes

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