Hydrochloric Acid → HCID 19985919, compound

Participants

Reaction Steps

4.50 ml of 1N hydrochloric acid are added to 0.70 g (2.25 mmol) of (E)-2-amino-6-(3-(4-cyano-phenyl)allyl)-4,5,7,8-tetrahydro-6H-thiazolo[5,4-d]azepine in 10 ml of ethanol and heating is carried out until the solution is clear. Then it is evaporated to dryness in vacuo. ethanol is added to the foamy residue, it is evaporated down once more and this procedure with ethanol is repeated three times more. Then the product is dissolved in ethanol and heated ard cooled in ice. The crystals are filtered off and dried at 100° C./4 torr. Yield: 0.70 g (81% of theory), Melting point: 247°-250° C. (decomp.).

Provenance & Evidence