HuagongsheHuagongshe Chemistry Print Report · For research reference only
O-Xylene → N-[3-(3,5-di-t-butyl-4-hydroxyphenyl)propanamido]-4-methylhexahydrophthalimide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | O-Xylene | HCID 7237 | — |
| Reactant | 3,5-Di-tert-butyl-4-hydroxyhydrocinnamic acid hydrazide | HCID 64865 | — |
| Reactant | Hexahydro-4-methylphthalic anhydride | HCID 86876 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-[3-(3,5-di-t-butyl-4-hydroxyphenyl)propanamido]-4-methylhexahydrophthalimide | HCID 19902401 | 100.5% |
Reaction Steps
A mixture of 4-methylhexahydrophthalic anhydride (32.8 g, 200 mmol), 3-(3,5-di-t-butyl-4-hydroxyphenyl)propanoic acid hydrazide (58.4 g, 200 mmol) and 650 ml of xylene was refluxed for 90 minutes under a nitrogen atmosphere with the azeotropic removal of water. The solvent was removed on a rotary evaporator to afford approximately 89 g of a white solid having a melting range of 87°-92° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05068356 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-a07343b029b64fe6bbdc278a4e0cf9f4 |
| Source note | uspto-grants-1991_11 |