Hydrochloric Acid → 3-(2,4-difluorophenyl)propanoic Acid

Participants

Reaction Conditions

Reaction Steps

33 g (0.154 mol) of ethyl 3-(2,4-difluorophenyl)propanoate are suspended in 250 ml of water. 60 ml of 10N sodium hydroxide solution and 30 ml of 40% tetrabutylammonium hydroxide solution are then added. The mixture is stirred vigorously and warmed. Everything has dissolved at about 50° C. The mixture is warmed further to 80° C. and then cooled to 5° C. On dropwise addition of 80 ml of concentrated hydrochloric acid, white crystals precipitate, which are filtered off and washed with ice-water. After drying in vacuo, 28.1 g (98% of theory) of white crystals of melting point 107°-108° C., which does not change even after recrystallization from 50% ethanol, are obtained.

Provenance & Evidence