反应详情

温度

200 °C

74.0 g (0.40 mol) of 3-(2,4-difluorophenyl)propanamide are mixed with 124 g (0.87 mol) of phosphorus pentoxide, and the mixture is heated to 200° C. in an oil bath in a flask fitted with falling condenser. The resultant liquid is distilled off by applying a vacuum of about 67 mbar. 48.5 g of a colourless oil, which is subjected to fractional distillation at 120°-124° C. in vacuo (19 mbar), are obtained. 46.5 g (70% of theory) of the expected product are obtained.

1. customfitted
2. distillationThe resultant liquid is distilled off
3. distillation48.5 g of a colourless oil, which is subjected to fractional distillation at 120°-124° C. in vacuo (19 mbar)
4. customare obtained