反应详情

33.4 g (0.20 mol) of 3-(2,4-difluorophenyl)propionitrile are dissolved in 200 ml of ethanol and, after 2.8 g of Raney nickel in ethanol have been added and after 34 g (2.0 mol) of ammonia gas have been injected, are hydrogenated using hydrogen gas in a pressurized reactor at 75°-80° C. The take-up of hydrogen is complete after about 3 hours. The reaction mixture is cooled, decompressed and filtered and then freed from solvent on a vacuum rotary evaporator. The resultant oil is subjected to fractional distillation at 89°-90° C. in vacuo (13 mbar). 26.0 g (76% of theory) of a colourless oil are obtained.

1. customat 75°-80° C
2. temperatureThe reaction mixture is cooled
3. filtrationfiltered
4. customfreed from solvent on a vacuum rotary evaporator
5. distillationThe resultant oil is subjected to fractional distillation at 89°-90° C. in vacuo (13 mbar)
6. custom26.0 g (76% of theory) of a colourless oil are obtained