Sodium Hydroxide → HCID 86743726, compound

Participants

Reaction Conditions

Reaction Steps

Phenylmethyl 9,9-bis(4-fluorophenyl)-3-hydroxy-8-(1-methyl-1H-tetrazol-5-yl)-5-oxo-6,8-nonadienoate (0.34 g, 0.62 mmole) was dissolved in tetrahydrofuran (4 mL) and water (1 mL). 1N Sodium hydroxide (0.62 mL, 0.62 mmole) was added, and the solution was stirred for 6 hours at 24° C. The mixture was diluted with water (10 mL) and washed with diethyl ether (3×50 mL). The aqueous portion was lyophilized to give 0.17 g (52%) of the title compound; m.p.=166°-180° C. (dec.).

Provenance & Evidence