HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene → 5,5-bis(4-fluorophenyl)-4-(1-ethyl-1H-tetrazol-5-yl)2,4-pentadienal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene | HCID 241 | — |
| Reactant | (Triphenylphosphoranylidene)acetaldehyde | HCID 75051 | — |
| Reactant | 3,3-Bis(4-fluorophenyl)-2-(1-ethyl-1H-tetrazol-5-yl)-2-propenal | HCID 14723826 | — |
| Product | 5,5-bis(4-fluorophenyl)-4-(1-ethyl-1H-tetrazol-5-yl)2,4-pentadienal | HCID 54555804 | 79.7% |
Reaction Steps
A solution of 3,3-bis(4-fluorophenyl)-2-(1-ethyl-1H-tetrazol-5-yl)-2-propenal (0.65 g, 1.9 mmoles) and 0.64 g (2.1 mmoles) of triphenylphosphoranylidene acetaldehyde in benzene was heated at reflux temperature for 2 hours. The solution was concentrated in vacuo and the residue purified by silica gel column chromatography eluting with CH2Cl2 to give 0.55 g (79.7%) of the title compound, m.p.=163°-165° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05068346 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-5195bde0e680414b9ceebe35b33655af |
| Source note | uspto-grants-1991_11 |