O-Toluidine → 2-Ethyl-6-isopropylaniline

HRID 974524Notes

Reaction equation

[CH2:1]([C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5])[CH3:2].N[C:11]1[C:12](C)=CC=C[CH:16]=1>>[CH2:1]([C:3]1[CH:9]=[CH:8][CH:7]=[C:6]([CH:11]([CH3:12])[CH3:16])[C:4]=1[NH2:5])[CH3:2]

Participants

Reactant 2

HCID 7242O-Toluidine

HCID 113572-Ethylaniline

Product 1

HCID 1044992-Ethyl-6-isopropylaniline

Procedure

The procedure of Example 6 was repeated, except that 2-ethylaniline was substituted for ortho-toluidine. Table 5 sets forth the reaction conditions and product selectivity.

Workup

customTable 5 sets forth the reaction conditions and product selectivity

Sources & evidence

ORD record: ord-e7d638af0012445da66adece8c5bf1da
Source dataset: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05068435

Reaction notes

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