反应详情

N,N-Dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride (10 g) was dissolved in a boiling mixture of acetone (110 ml) and water (1.2 ml). The solution was filtered whilst hot and the volume of the filtrate reduced by the removal by distillation of 80 ml of solvent. The product was collected from the cooled concentrate by filtration and dried in vacuo at ambient temperature to give N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate (m.p. 195° C.).

1. filtrationThe solution was filtered whilst hot and the volume of the filtrate
2. customreduced by the removal by distillation of 80 ml of solvent
3. customThe product was collected from the cooled
4. concentrationconcentrate by filtration
5. customdried in vacuo at ambient temperature