反应详情

A sample (1 g) of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride which had been dehydrated in vacuo at 70° C. for 7 hours was dissolved in a boiling mixture of water (0.5 ml) and an organic solvent (4.5 ml). The solution was allowed to cool to ambient temperature and then stored at 4° C. for three hours. A solid was collected by filtration, washed with the organic solvent and dried in vacuo at ambient temperature for 18 hours to give N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate the melting point of which is given below.

1. filtrationA solid was collected by filtration
2. washwashed with the organic solvent
3. customdried in vacuo at ambient temperature for 18 hours