Toluene → 1-[1-(4-Chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine--hydrogen chloride--water (1/1/1)

Participants

Reaction Conditions

Reaction Steps

A sample (5 g) of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride was heated with a mixture of toluene (30 ml) and propan-2-ol (3 ml) to 90° C. and allowed to cool to 72° C. Water (0.9 ml) was added and the mixture cooled to 25° C. and then placed in an ice-water bath for 30 minutes. A solid was collected by filtration, washed with cold toluene and dried by suction at ambient temperature to give N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate [m.p. 193°-195° C. (shrinks 150°-155° C.)].

Provenance & Evidence