Methyl Isocyanate → N-Methyl 3-phenoxy-1-azetidinecarboxamide

HRID 974575Notes

Reaction equation

CS([O-])(=O)=O.[O:6]([CH:13]1[CH2:16][NH:15][CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[CH3:17][N:18]=[C:19]=[O:20]>>[CH3:17][NH:18][C:19]([N:15]1[CH2:16][CH:13]([O:6][C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:14]1)=[O:20]

Participants

Reactant 3

HCID 12228Methyl Isocyanate

HCID 85257Methanesulfonate

HCID 128125013-Phenoxyazetidine

Product 1

HCID 13420164N-Methyl 3-phenoxy-1-azetidinecarboxamide

Procedure

The compound was prepared from the methane sulfonate of 3-phenoxyazetidine and methylisocyanate as described in Example 1 of U.S. Pat. No. 4,226,861, m.p. 139°-141° C.

Sources & evidence

ORD record: ord-67bf713889f84e829c19ea1779994508
Source dataset: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05068231

Reaction notes

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