Methyl Isocyanate → 3-(4-Trifluoromethylphenoxy)-N-methyl-1-azetidinecarboxamide

HRID 974576Notes

Reaction equation

[F:1][C:2]([F:15])([F:14])[C:3]1[CH:13]=[CH:12][C:6]([O:7][CH:8]2[CH2:11][NH:10][CH2:9]2)=[CH:5][CH:4]=1.[CH3:16][N:17]=[C:18]=[O:19]>>[CH3:16][NH:17][C:18]([N:10]1[CH2:9][CH:8]([O:7][C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:14])[F:15])=[CH:13][CH:12]=2)[CH2:11]1)=[O:19]

Participants

Reactant 2

HCID 12228Methyl Isocyanate

HCID 128124993-[4-(Trifluoromethyl)phenoxy]azetidine

Product 1

HCID 134201663-(4-Trifluoromethylphenoxy)-N-methyl-1-azetidinecarboxamide

Procedure

The compound was prepared from 3-[4-(trifluoromethyl)phenoxy]azetidine and methylisocyanate as described in Example 3 of U.S. Pat. No. 4,226,861, m.p. 154°-157° C.

Sources & evidence

ORD record: ord-e6fb84caa6344232bcd66436c727a899
Source dataset: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05068231

Reaction notes

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