HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → 4'-Phenoxyacetophenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Diphenyl Ether | HCID 7583 | — |
| Reactant | Lithium Chloride | HCID 433294 | — |
| Reactant | Aluminum(III) Chloride | HCID 6451240 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | 4'-Phenoxyacetophenone | HCID 236783 | 90.3% |
Reaction Steps
To an agitated mixture of lithium chloride (3.18 g., 0.075 mole) and aluminium chloride (20 g., 0.15 mol) in dichloroethane (20 ml) was slowly added diphenyl ether (8.51 g., 0.05 mole) and acetyl chloride (3.93 g., 0.05 mol) in dichloroethane (7 ml) following the procedure of example 9. The 4-phenoxyacetophenone obtained (9.57 g., 90.3% yield, m.p. 43.5°-51° C.) had a IH NMR purity of 90%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05068447 |
| Source dataset | uspto-grants-1991_11 |
| ORD ID | ord-d541164e59d44e3d8d86ff0aeb6b4903 |
| Source note | uspto-grants-1991_11 |