Thionyl Chloride → 2-Chloro-4,5-difluorobenzoyl chloride

HRID 974660Notes

Reaction equation

HRID 974660 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:15])=O>>[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([Cl:15])=[O:5]

Participants

3

Reactant 2

HCID 24386Thionyl Chloride2×HCID 7371712-Chloro-4,5-difluorobenzoic acid

Product 1

HCID 101982172-Chloro-4,5-difluorobenzoyl chlorideYield 92.9%

Procedure

Into a 300 cc glass reactor, 100 g of 2-chloro-4,5-difluorobenzoic acid and 200 g of thionyl chloride were charged and stirred at about 60° to 70° C. for 3 hours. Unreacted thionyl chloride was distilled off, and the residue was subjected to distillation under reduced pressure to obtain 101.8 g of 2-chloro-4,5-difluorobenzoyl chloride. The physical properties of the obtained 2-choloro-4,5-difluorobenzoyl chloride were as follows.

Workup

  1. distillationwas distilled off
  2. distillationthe residue was subjected to distillation under reduced pressure

Sources & evidence

ORD record
ord-bc58c98db6cc44f8ae70e69e9fc087e9
Source dataset
uspto-grants-1991_11
Patent number
US05068449

Reaction notes

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