Ethyl 3-(2-chloro-4,5-difluorophenyl)-3-oxopropanoate → Ethyl 2-(2-chloro-4,5-difluorobenzoyl)-3-ethoxyacrylate

Participants

Reaction Steps

Into a 200 cc glass reactor equipped with a stirrer, 26.3 g of ethyl 2-chloro-4,5-difluorobenzoylacetate, 23.7 g of ethyl ortho-formate and 40 ml of acetic anhydride were charged, and reacted at a reaction temperature of from 120° to 135° C. After completion of the reaction, the reaction mixture was concentrated by distillation under reduced pressure to obtain 31.5 g of the desired compound as the residue.

Provenance & Evidence