Pyridine → HCID 19986100, compound

HRID 974673Notes

Reaction equation

[P:1]([O-:40])([O:36][CH2:37][CH2:38]Br)([O:3][CH2:4][CH:5]([O:24][C:25]1[CH:29]=[C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[O:27][N:26]=1)[CH2:6][O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[O:2].[N:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1>>[P:1]([O-:40])([O:36][CH2:37][CH2:38][N+:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)([O:3][CH2:4][CH:5]([O:24][C:25]1[CH:29]=[C:28]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[O:27][N:26]=1)[CH2:6][O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])=[O:2]

Participants

Reactant 2

HCID 1049Pyridine

HCID 19986049HCID 19986049, compound

Product 1

HCID 19986100HCID 19986100, compound

Procedure

0.875 g of the crude (2RS)-3-hexadecyloxy-2-(5-phenyl-3-isoxazolyloxy)propyl 2-bromoethyl phosphate obtained as described in the first part of Example 7 was reacted with pyridine in a similar manner to that described in Example 3 to afford 0.507 g of the title compound as a colorless oil.

Sources & evidence

ORD record: ord-3bd2183a000d499cbb49fee20a2e25ba
Source dataset: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05068340

Reaction notes

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