Trimethylamine → HCID 19986069, compound

HRID 974675Notes

Reaction equation

[P:1]([O-:38])([O:34][CH2:35][CH2:36]Br)([O:3][CH2:4][CH:5]([O:28][C:29]1[CH:33]=[CH:32][O:31][N:30]=1)[CH2:6][O:7][C:8](=[O:27])[NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[O:2].[CH3:39][N:40]([CH3:42])[CH3:41]>>[P:1]([O-:38])([O:34][CH2:35][CH2:36][N+:40]([CH3:42])([CH3:41])[CH3:39])([O:3][CH2:4][CH:5]([O:28][C:29]1[CH:33]=[CH:32][O:31][N:30]=1)[CH2:6][O:7][C:8](=[O:27])[NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[O:2]

Participants

Reactant 2

HCID 1146Trimethylamine

HCID 19986121HCID 19986121, compound

Product 1

HCID 19986069HCID 19986069, compound

Procedure

11(b) 0.800 g of (2RS)-3-(N-heptadecylcarbamoyloxy)-2-(3-isoxazolyloxy)propyl 2-bromoethyl phosphate [prepared as described in step (a) above] was reacted with trimethylamine in a similar manner to that described in Example 1(b), to give 0.640 g of the title compound as viscous oil.

Sources & evidence

ORD record: ord-d84e2448a62c4f4b98852533f996517b
Source dataset: uspto-grants-1991_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05068340

Reaction notes

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