Pyridine → HCID 67870568, compound

HRID 974676Notes

Reaction equation

HRID 974676 reaction equation
[P:1]([O-:38])([O:34][CH2:35][CH2:36]Br)([O:3][CH2:4][CH:5]([O:28][C:29]1[CH:33]=[CH:32][O:31][N:30]=1)[CH2:6][O:7][C:8](=[O:27])[NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[O:2].[N:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1>>[P:1]([O-:38])([O:34][CH2:35][CH2:36][N+:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)([O:3][CH2:4][CH:5]([O:28][C:29]1[CH:33]=[CH:32][O:31][N:30]=1)[CH2:6][O:7][C:8](=[O:27])[NH:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[O:2]

Participants

3

Reactant 2

HCID 1049PyridineHCID 19986121HCID 19986121, compound

Product 1

HCID 67870568HCID 67870568, compound

Procedure

0.800 g of (2RS)-3-(N-heptadecylcarbamoyloxy)-2-(3-isoxazolyloxy)propyl 2-bromoethyl phosphate [prepared as described in Example 11(a)] was reacted with pyridine in a similar manner to that described in Example 3, to afford 0.549 g of the title compound as a viscous resinous material.

Sources & evidence

ORD record
ord-47938a27c9c749b290d78cc12ef3cda7
Source dataset
uspto-grants-1991_11
Patent number
US05068340

Reaction notes

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