Acetic Anhydride → HCID 19986057, compound

Participants

Reaction Steps

0.370 g of (2RS)-3-(5-hexadecyl-3-isoxazolyloxy)-2-(3-isoxazolyloxy)propyl N-(2-pyridylmethyl)carbamate (prepared as described in Example 30), 0.60 ml of acetic anhydride and 0.733 g of 4-(N,N-dimethylamino)pyridine were dissolved in 10 ml of toluene, and the mixture was stirred on an oil bath kept at 90° C. for 48 hours. The solvent was distilled off, and the residue was purified by column chromatography through 15 g of silica gel and by medium pressure liquid chromatography using a Lobar B column, 0.308 g of the title compound was obtained, as an oil, from the fractions eluted with methylene chloride.

Provenance & Evidence