HCID 19986091, compound → HCID 54314252, compound

Participants

Reaction Steps

A solution of 9.118 g of diethyl 2-(5-phenyl-3-isoxazolyloxy)malonate (prepared as described in Preparation 22) in 50 ml of tetrahydrofuran wa added dropwise to a suspension of 4.33 g of lithium aluminum hydride in 50 ml of tetrahydrofuran, whilst ice-cooling. The reaction mixture was then heated under reflux for 5 hours, after which it was worked-up in a similar manner to that described in Preparation 20, to afford 4.394 g if the title compound as white crystals, melting at 117°-119° C. (from a mixture of methanol and methylene chloride).

Provenance & Evidence