反应详情

6-Bromohexanoyl chloride (2 g, 9.37 mmol) was added to t-butanol (6.98 g, 93.7 mmol) under an inert atmosphere. The reaction mixture was stirred overnight and then was concentrated in vacuo, dissolved in ethyl acetate (150 ml), washed with saturated aqueous sodium bicarbonate and 10% aqueous citric acid, and dried over magnesium sulfate to yield t-butyl 6-bromohexanoate (2.02 g, 80% yield).

1. concentrationwas concentrated in vacuo
2. dissolutiondissolved in ethyl acetate (150 ml)
3. washwashed with saturated aqueous sodium bicarbonate and 10% aqueous citric acid
4. dry with materialdried over magnesium sulfate