Sodium Hydroxide → Glycine tert-butyl ester

Glycine t-butyl ester hydrochloride (2.51 g, 15 mmol) was treated with 10N aqueous sodium hydroxide (1.6 ml) and extracted with dichloromethane (50 ml). The dichloromethane solution was back washed with saturated aqueous sodium chloride (2×5 ml), dried over sodium sulfate, and concentrated in vacuo to yield the glycine t-butyl ester (1.38 g, 70% yield).

1. extractionextracted with dichloromethane (50 ml)
2. washThe dichloromethane solution was back washed with saturated aqueous sodium chloride (2×5 ml)
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated in vacuo

ORD record

ord-92f444f82f3c4e59af9f7f196b2823da

Source dataset

uspto-grants-1997_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05607691