5-Methoxyindan-1-one → 5-Hydroxy-1-indanone

Participants

Reaction Steps

To a solution of 5-methoxy-1-indanone (2 g, 12.3 mmol) in benzene (50 ml) was added AlCl3 (4 g, 31 mmol). The mixture was heated at reflux for 5 hours and extracted with ethyl acetate. The organic phase was evaporated and purified by flash chromatography, eluting with CH2Cl2 /CH3CN (90/10) to give 5-hydroxy-1-indanone as a yellow solid (1.65 g; 90%).

Provenance & Evidence