HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Methoxy-alpha-tetralone → 6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Methoxy-alpha-tetralone | HCID 14112 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone | HCID 4679494 | — |
Reaction Steps
A mixture of 6-methoxy-1-tetralone (5 g, 28.4 mmol) in acetic acid (50 ml) and 48% bromhydric acid (25 ml) was heated at reflux for 7 hours. After extraction with CH2Cl2 and evaporation, the residue was purified by flash chromatography (AcoEt/petroleum ether 45/55) to give 6-hydroxy-1-tetralone as a foam (3.9 g; 84.7%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05607928 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-2d8a9fc12afa4e14b139947e00fdd672 |
| Source note | uspto-grants-1997_03 |