Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 2-Thiophenecarboxaldehyde | HCID 7364 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 4-methoxy-2,3-dihydro-1H-inden-1-one | HCID 4547491 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 54371093 | HCID 54371093 | 90% |
Reaction Steps
To 4-methoxy-1-indanone (0.1 g; 0.62 mmol) were added thiophene-2-carboxaldehyde (87.5 μl ; 0.93 mmol), piperidine (18.5 μl ; 0.18 mmol) and acetic acid (10.7 μl ; 0.18 mmol). After heating at 130° C. for 90 minutes the mixture was taken up in CH2Cl2, washed with water and purified by flash chromatography, eluting with petroleum ether/ethyl acetate (95/5) to give 4-methoxy-2-(2-thienylmethylene)-1-indanone (140 mg; 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05607928 |
|---|
| Source dataset | uspto-grants-1997_03 |
|---|
| ORD ID | ord-5d261c75f25f4b1a9cc61a7ea2abca42 |
|---|
| Source note | uspto-grants-1997_03 |
|---|
