HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluorobenzonitrile → HCID 10541803, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluorobenzonitrile | HCID 67855 | — |
| Reactant | 2-Amino-4-(trifluoromethyl)benzenethiol hydrochloride | HCID 2734678 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 10541803 | HCID 10541803 | — |
Reaction Steps
Using a procedure analagous to that of Example 3, 4-trifluoromethyl-2-aminothiophenol hydrochloride (11.48 g, 50 mmol) was combined with 2-fluorobenzonitrile in DMF as solvent (100 ml) to give crude 2-(4-trifluoromethyl-2-aminophenylthio) benzonitrile (6.84 g). Hydrolysis and subsequent condensation gave the title compound as off-white crystals from ethanol (1.1 g, m.p. 233°-235° C., Rf 0.21, CH2Cl2 /MeOH 50:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05607929 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-ad25b89aec5245c59bb31172e9e04c97 |
| Source note | uspto-grants-1997_03 |