2-Bromo-4,6-dimethylpyridine → (+/-)-2-[1-(4-chlorobenzoyl)propyl]-4-[6-[4-(4,6-dimethyl-2-pyridinyl)-1-piperazinyl]-3-pyridinyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Participants

Reaction Conditions

Reaction Steps

(±)-2-[1-(4-chlorobenzoyl)propyl]-2,4-dihydro-4-[6-(1-piperazinyl)-3-pyridinyl]-3H-1,2,4-triazol-3-one (6.02 g) and 2-bromo-4,6-dimethylpyridine (5.25 g) were stirred and heated under N2 at 140° C. for 2 days. The mixture was dissolved in CH2Cl2 and purified on a glass filter over silica gel (eluent: CH2Cl2 /CH3OH 100/0 to 97/3). The pure fractions were collected and evaporated, yielding 3.6 g (48%) of (±)-2-[1-(4-chlorobenzoyl)propyl]-4-[6-[4-(4,6-dimethyl-2-pyridinyl)-1-piperazinyl]-3-pyridinyl]-2,4-dihydro-3H-1,2,4-triazol-3-one; mp. 113.2° C. (comp. 32).

Provenance & Evidence