Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Chloro-4-methoxypyrimidine | HCID 588935 | — |
| Reactant | 1-(5-Nitropyridin-2-yl)piperazine | HCID 2928799 | — |
| Solvent | Sulfolane | HCID 31347 | — |
| Product | HCID 19969506 | HCID 19969506 | 43.3% |
Reaction Steps
A mixture of 2-chloro-4-methoxypyrimidine (29 g) and 1-(5-nitro-2-pyridinyl)piperazine (35 g) in tetrahydrothiophene 1,1-dioxide (50 ml) was stirred at 130° C. for 1 hour. The mixture was poured into sodium carbonate and water, stirred for 30 minutes and extracted with CH2Cl2. The organic layer was dried over MgSO4, filtered and evaporated. The residue was triturated in diisopropyl ether, yielding 23 g (43%) of 4-methoxy-2-[4-(5-nitro-2-pyridinyl)-1-piperazinyl]pyrimidine (interm. 10).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05607932 |
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| Source dataset | uspto-grants-1997_03 |
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| ORD ID | ord-599da87ba36f4ac498abaa3e0d6f7f43 |
|---|
| Source note | uspto-grants-1997_03 |
|---|
