HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2R)-2-methoxypropanoic acid → 2-Methoxy-1-propanol, (2S)-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2R)-2-methoxypropanoic acid | HCID 2733584 | — |
| Reactant | 2-Methoxy-1-propanol, (2R)- | HCID 2733588 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Product | 2-Methoxy-1-propanol, (2S)- | HCID 642402 | — |
| Product | 2-methoxypropanoic acid, (S)- | HCID 5702566 | — |
Reaction Steps
By reduction of the (+)-(R)-2-methoxy-propionic acid known from the prior art with lithium aluminium hydride (LiAlH4) the (-)-(R)-2-methoxy-propanol is obtained with a boiling point of 70° C. under a pressure of 76 mbar and a specific rotation of [α]D25 =-15.8° (c=100). The corresponding (+)-(S)-2-methoxy-propanol with a boiling point of 70° C. under a pressure of 76 mbar and a rotation of [α]D25 =+16.5° (c=100) is obtained analogously from the equally well known (-)-(S)-2-methoxy-propionic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05607941 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-d1ae2497dd3745958d0a71d4a3eb8efa |
| Source note | uspto-grants-1997_03 |