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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 974874Generated: October 27, 2026

(2R)-2-methoxypropanoic acid → 2-Methoxy-1-propanol, (2S)-

https://huagongshe.com/reaction/974874

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2R)-2-methoxypropanoic acidHCID 2733584—
Reactant2-Methoxy-1-propanol, (2R)-HCID 2733588—
ReactantAluminium lithium hydrideHCID 21226445—
Product2-Methoxy-1-propanol, (2S)-HCID 642402—
Product2-methoxypropanoic acid, (S)-HCID 5702566—

Reaction Steps

By reduction of the (+)-(R)-2-methoxy-propionic acid known from the prior art with lithium aluminium hydride (LiAlH4) the (-)-(R)-2-methoxy-propanol is obtained with a boiling point of 70° C. under a pressure of 76 mbar and a specific rotation of [α]D25 =-15.8° (c=100). The corresponding (+)-(S)-2-methoxy-propanol with a boiling point of 70° C. under a pressure of 76 mbar and a rotation of [α]D25 =+16.5° (c=100) is obtained analogously from the equally well known (-)-(S)-2-methoxy-propionic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05607941
Source datasetuspto-grants-1997_03
ORD IDord-d1ae2497dd3745958d0a71d4a3eb8efa
Source noteuspto-grants-1997_03