HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → trans-3-Amino-1-benzyl-4-hydroxy-pyrrolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-Benzyl-6-oxa-3-azabicyclo(3.1.0)hexane | HCID 9815370 | — |
| Product | trans-3-Amino-1-benzyl-4-hydroxy-pyrrolidine | HCID 11332997 | — |
Reaction Steps
8.9 g (50 mmol) of 3-benzyl-6-oxa-3-azabicyclo[3.1.0]hexane are heated in 75 ml of ammonia solution (25% strength) at 120° C. in an autoclave for 8 hours. The solution is concentrated and the residue is distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05607942 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-1d73cae6917b4ac7977504590f550937 |
| Source note | uspto-grants-1997_03 |