Water → trans-1-Benzyl-4-hydroxy-3-(2-hydroxyethyl-methylamino)-pyrrolidine

HRID 974890Notes

Reaction equation

HRID 974890 reaction equation
[CH2:1]([N:8]1[CH2:13][CH:12]2[CH:10]([O:11]2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:14][NH:15][CH:16](O)[CH3:17].[OH2:19]>>[CH2:1]([N:8]1[CH2:9][C@@H:10]([OH:11])[C@H:12]([N:15]([CH2:16][CH2:17][OH:19])[CH3:14])[CH2:13]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 962WaterHCID 5247031N-MethylaminoethanolHCID 98153703-Benzyl-6-oxa-3-azabicyclo(3.1.0)hexane

Product 1

HCID 15069974trans-1-Benzyl-4-hydroxy-3-(2-hydroxyethyl-methylamino)-pyrrolidine

Procedure

17.5 g (0.1 mol ) of 3-benzyl-6-oxa-3-azabicyclo[3.1.0]-hexane are reacted with 17 g (0.1 mol ) of methylamino-ethanol in 200 ml of water analogously to Example D a).

Sources & evidence

ORD record
ord-8b558268030542c6812a68e69676171d
Source dataset
uspto-grants-1997_03
Patent number
US05607942

Reaction notes

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