HCID 15069996, compound → Ethyl 3-(hydroxymethyl)-4-(methylamino)pyrrolidine-1-carboxylate

Participants

Reaction Steps

10 g (50 mmol) of ethyl 2-methyl-3-oxa-2,7-diazabicyclo[3.3.0]octane-7-carboxylate (Example H d)) are hydrogenated in 200 ml of ethanol on 3 g of Pd-on-active charcoal (10% of Pd) at 50° C. under 50 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.

Provenance & Evidence