HCID 15070022, compound → 2-Methyl-4-oxa-2,8-diazabicyclo[4.3.0]nonane

HRID 974919Notes

Reaction equation

HRID 974919 reaction equation
[CH3:1][N:2]1[CH2:10][O:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5](C(OCC)=O)[CH2:6]2>O>[CH3:1][N:2]1[CH2:10][O:9][CH2:8][CH:7]2[CH:3]1[CH2:4][NH:5][CH2:6]2

Participants

3

Reactant 1

HCID 15070022HCID 15070022, compound

Product 1

HCID 150700232-Methyl-4-oxa-2,8-diazabicyclo[4.3.0]nonane

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

9 g (42 mmol) of ethyl 2-methyl-4-oxa-2,8-diazabicyclo[4.3.0]nonane-8-carboxylate are heated under reflux with 28 g of Ba(OH)2 ·8H2O in 280 ml of water overnight. The BaCO3 is filtered off with suction, the filtrate is concentrated and the residue is boiled up with dioxane. The dioxane solution is concentrated and the residue is distilled.

Workup

  1. filtrationThe BaCO3 is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. concentrationThe dioxane solution is concentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-3aaff2ae6d324ef9b1c15dbaf73e17a2
Source dataset
uspto-grants-1997_03
Patent number
US05607942

Reaction notes

Loading…