HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 178471887, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cyclopropylamine | HCID 69828 | — |
| Reactant | Ethyl 2-(2,4-dichloro-3,6-difluorobenzoyl)-3-ethoxyacrylate | HCID 53750212 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178471887 | HCID 178471887 | 87.6% |
Reaction Steps
15.6 g of ethyl 2-(2,4-dichloro-3,6-difluorobenzoyl)-3-ethoxy-acrylate are dissolved in 50 ml of ethanol, and 2.75 g of cyclopropylamine are added dropwise, while cooling. The mixture is stirred at room temperature for 1 hour, 50 ml of water are added, while cooling with ice, and the precipitate is filtered off with suction, rinsed with ethanol/H2O (1:1) and dried. 14.1 g of ethyl 2-(2,4-dichloro-3,6-difluorobenzoyl)-3-cyclopropylamino-acrylate of melting point 106°-107° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05607942 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-c8198dc26f5e48928212d3565196134b |
| Source note | uspto-grants-1997_03 |