1-(2-Bromoethyl)-4-chlorobenzene → HCID 19970179, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(2-cyano-2,2-diphenylethyl)pyridine (1.70 g, 6 mmol) (see Preparation 5) and 4-chlorophenethyl bromide (1.10 g, 5 mmol) was heated at 115° C. for 26 hours, allowed to cool to room temperature and triturated with ethanol:ether=1:2 (15 ml). The resulting solid was collected, washed with ether, dried and recrystallised first from water and then from ether/2-propanol to give the title compound (0.37 g, 14%) as colourless crystals, m.p. 210°-211° C.

Provenance & Evidence