Water → HCID 2747423, compound

HRID 974981Notes

Reaction equation

HRID 974981 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:4][CH2:3]1.[C:15]([N:19]=[C:20]=[S:21])([CH3:18])([CH3:17])[CH3:16].O>ClCCl>[CH2:8]([N:5]1[CH2:6][CH2:7][CH:2]([NH:1][C:20]([NH:19][C:15]([CH3:18])([CH3:17])[CH3:16])=[S:21])[CH2:3][CH2:4]1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 962WaterHCID 11544tert-Butyl isothiocyanateHCID 4158521-Benzyl-4-piperidylamine

Product 1

HCID 2747423HCID 2747423, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

24.93 g of 4-amino-1-benzylpiperidine are dissolved in 300 ml of dichloromethane and then 16.7 ml of tert-butylisothiocyanate are added dropwise and at room temperature. The reaction mixture is stirred at room temperature for 5 hours and then water is added and the mixture is allowed to settle. The organic phase is separated, dried over sodium sulphate and evaporated. The residue obtained is crystallized from petroleum ether in order to give white crystals which melt at 137° C.; yield: 88%.

Workup

  1. customThe organic phase is separated
  2. dry with materialdried over sodium sulphate
  3. customevaporated
  4. customThe residue obtained
  5. customis crystallized from petroleum ether in order
  6. customto give white crystals which
  7. custommelt at 137° C.

Sources & evidence

ORD record
ord-9f503130f72b4577a2786ce988d32793
Source dataset
uspto-grants-1997_03
Patent number
US05607952

Reaction notes

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