Water → HCID 15388918, compound

Participants

Reaction Conditions

Reaction Steps

17.75 g of potassium carbonate and 4.3 ml of methylbromoacetate are added to 14.8 g of 4-{2-[(piperid-4-yl) amino]-1,3-thiazol-4-yl}benzonitrile dihydrochloride in 150 ml of N,N-dimethylformamide and the reaction mixture is heated at 50° C. for 2 hours. It is poured over water, extracted with ethyl acetate and the organic phase is washed with water, and then dried over sodium sulphate and concentrated under vacuum. The residue crystallizes from isopropyl ether to give beige crystals which melt at 172° C.; yield 86%.

Provenance & Evidence