N-Carbethoxyphthalimide → N-(1-benzylpyrrolidin-3-yl)phthalimide

HRID 975005ノート

反応式

HRID 975005 の反応式
[NH2:1][CH:2]1[CH2:6][CH2:5][N:4]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:3]1.C(OC(N1[C:23](=[O:24])[C:22]2=[CH:25][CH:26]=[CH:27][CH:28]=[C:21]2[C:20]1=[O:29])=O)C>ClC>[CH2:7]([N:4]1[CH2:5][CH2:6][CH:2]([N:1]2[C:23](=[O:24])[C:22]3=[CH:25][CH:26]=[CH:27][CH:28]=[C:21]3[C:20]2=[O:29])[CH2:3]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

参加物

4

反応物 2

HCID 31187N-CarbethoxyphthalimideHCID 27566131-Benzyl-3-aminopyrrolidine

生成物 1

HCID 6711061N-(1-benzylpyrrolidin-3-yl)phthalimide収率 73.3%

試薬・触媒・溶媒 1

HCID 6327Methyl Chloride溶媒

実験手順

10.0 g of 3-amino-1-benzylpyrrolidine was dissolved into 10 ml of chloromethane, to which 12.4 g of N-ethoxycarbonylphthalimide was added and stirred at a room temperature for 10 hours. The solvent was distilled off, diethyl ether was added and insoluble matters were filtered out. The filtrate was concentrated and purified on silica gel column chromatography, to obtain 12.70 g of the above-captioned compound (yield: 73%)

後処理

  1. additionwas added
  2. distillationThe solvent was distilled off
  3. additiondiethyl ether was added
  4. filtrationinsoluble matters were filtered out
  5. concentrationThe filtrate was concentrated
  6. custompurified on silica gel column chromatography

出典と根拠

ORDレコード
ord-132544e9f0484098ab1594f7a0dadfe7
出典データセット
uspto-grants-1997_03
特許番号
US05607953

反応ノート

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