反应详情

3-Chloropentane-2,4-dione (46.5 g), propionamide (50 g) and propionic acid (151 g) were heated at 145° C. for 5 hours. The mixture was cooled to room temperature, then basified to pH 10 using 10M aqueous sodium hydroxide, and extracted with dichloromethane. The combined extracts were washed with brine, dried and the solvent removed to leave a brown oil which was purified by vacuum distillation, b.p. 70° C. at 2 mbar.

1. extractionextracted with dichloromethane
2. washThe combined extracts were washed with brine
3. customdried
4. customthe solvent removed
5. customto leave a brown oil which
6. distillationwas purified by vacuum distillation, b.p. 70° C. at 2 mbar