1-(4-Methyloxazol-5-yl)ethanone → 1-(2-Furyl)-1-(4-methyl-5-oxazolyl)ethanol

Participants

Reaction Steps

5-Acetyl-4-methyloxazole (4 g) in dry diethylether was added dropwise to a stirred solution of 2-lithiofuran (1 equivalent) in diethylether at -20° C. The mixture was allowed to warm to room temperature and was then left overnight. Work-up and flash chromatography then gave the title compound as a white solid, m.p. 73°-75° C.

Provenance & Evidence