HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylpyrrole → 1-(2,4-Dimethyl-5-thiazolyl)-1-(1-methyl-2-pyrrolyl)ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylpyrrole | HCID 7304 | — |
| Reactant | N,N,N',N'-Tetramethylethylenediamine | HCID 8037 | — |
| Reactant | 2,4-Dimethyl-5-acetylthiazole | HCID 520888 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-(2,4-Dimethyl-5-thiazolyl)-1-(1-methyl-2-pyrrolyl)ethanol | HCID 18936331 | — |
Reaction Steps
n-Butyllithium (2.5M solution in hexanes, 20 ml) in dry diethyl ether was cooled to -70° C. under dry nitrogen and TMEDA (5.8 g) was added. After 5 minutes, 1-methylpyrrole (5.4 g) in diethyl ether was added dropwise. After a further 15 minutes, 5-acetyl-2,4-dimethylthiazole (4.5 ml) was added dropwise. After 30 minutes the mixture was allowed to warm to room temperature and was then worked up in the usual fashion.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05607956 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-5df2a8940a314c8196965cb6537c3385 |
| Source note | uspto-grants-1997_03 |