HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl vinyl ketone → 3-(N-Benzyloxycarbonyl-2(R)-pyrrolidinylmethyl)-5-(3-oxo-1-but-1-enyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl vinyl ketone | HCID 6570 | — |
| Reactant | (R)-Benzyl 2-((5-bromo-1H-indol-3-yl)methyl)pyrrolidine-1-carboxylate | HCID 22859561 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(N-Benzyloxycarbonyl-2(R)-pyrrolidinylmethyl)-5-(3-oxo-1-but-1-enyl)-1H-indole | HCID 54404692 | — |
Reaction Steps
Obtained by a procedure similar to that described in Example 1, from 3-(N-benzyloxycarbonyl-2(R)-pyrrolidinylmethyl)-5-bromo-1H-indole (Preparation 1) and methyl vinyl ketone, as a foam. Rf 0.60 (SS 7). [α]D25 -51° (c=0.1, CH3OH). Found: C,74.16; H,6.39; N,6.92. C25H26N2O3 requires C,74.60; H,6.51; N,6.96%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05607960 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-951a8f598b36474fbe8f5a30543781e6 |
| Source note | uspto-grants-1997_03 |