HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Ethyl-1-penten-3-ol → 3-(N-Benzyloxycarbonyl-2(R)-pyrrolidinylmethyl)-5-(3-ethyl-3-hydroxy-1-pent-1-enyl)-1H-indole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Ethyl-1-penten-3-ol | HCID 120513 | — |
| Reactant | (R)-Benzyl 2-((5-bromo-1H-indol-3-yl)methyl)pyrrolidine-1-carboxylate | HCID 22859561 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(N-Benzyloxycarbonyl-2(R)-pyrrolidinylmethyl)-5-(3-ethyl-3-hydroxy-1-pent-1-enyl)-1H-indole | HCID 53671250 | — |
Reaction Steps
Obtained by a procedure similar to that described in Example 1, from 3-(N-benzyloxycarbonyl-2(R)-pyrrolidinylmethyl)-5-bromo-1H-indole (Preparation 1) and 3-ethylpent-1-en-3-ol (Example 9(a)), as a foam. Rf 0.66 (SS 7). [α]D25 -27° (c=0.1, CH3OH). Found: C,75.33; H,+.29; N,5.65. C28H34N2O3 requires C,75.30; H,7.67; N,6.26%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05607960 |
| Source dataset | uspto-grants-1997_03 |
| ORD ID | ord-6eae00ee7993437abc540579c09ea6d8 |
| Source note | uspto-grants-1997_03 |