Dichloromethane → HCID 22611262, compound

Participants

Reaction Steps

A mixture of the title compound of Example 56 (160 mg, 0.62 mmol), activated manganese dioxide (1.6 g), dichloromethane (12 ml) and acetonitrile (3 ml) was stirred for 16 hours at room temperature, when a further portion of activated manganese dioxide (0.6 g) was added. After a further 4 days, the reaction mixture was filtered and the filtrate evaporated under reduced pressure. The residue was purified by column chromatography on silica gel, eluting with 0.880 aqueous ammonia:methanol:dichloromethane (1:12:5:86.5), to afford the title compound (35 mg). Rf 0.35 (SS 15). Found: C,73.30; H,7.76; N,10.65. C16H20N2O; 0.17 CH2Cl2 requires C,73.73; H,7.75; N,10.71%.

Provenance & Evidence