Hydrochloric Acid → (R)-1-(2-((amino)oxy)ethyl)-3-piperidinecarboxylic acid dihydrochloride

Participants

Reaction Conditions

Reaction Steps

A mixture of the above ester (3.3 g, 10 mmol), acetic acid (7 ml) and concentrated hydrochloric acid (4.2 ml) was heated at 80° C. for 1.5 h. The reaction mixture was cooled to 5° C., filtered and the filterpad washed with cold acetic acid (2×2 ml). The solvent was evaporated from the filtrate in vacuo and the residue was dissolved in warm absolute ethanol (10 ml) and left for crystallisation. The precipitate was collected and dried in vacuo to give 1.1 g of (R)-1-(2-((amino)oxy)ethyl)-3-piperidinecarboxylic acid dihydrochloride.

Provenance & Evidence