Ethanol → 1,3-Diphenylacetone oxime

HRID 975257Notes

Reaction equation

HRID 975257 reaction equation
[C:1]1([CH2:7][C:8](=O)[CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl-].[OH:18][NH3+:19].C(O)C.C(=O)([O-])[O-].[Na+].[Na+]>O>[C:1]1([CH2:7][C:8](=[N:19][OH:18])[CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

6

Reactant 4

HCID 702EthanolHCID 75931,3-Diphenyl-2-propanoneHCID 10340Sodium CarbonateHCID 21645Hydroxylamine HCl

Product 1

HCID 745181,3-Diphenylacetone oximeYield 90.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a solution of 1,3-diphenyl-2-propanone (5.0 g, 24 mmol) and hydroxylammonium chloride (3.3 g, 48 mmol) in a mixture of absolute ethanol (30 ml) and water (10 ml) was carefully added a solution of sodium carbonate (13.2 g, 96 mmol) in water (30 ml). The resulting mixture was stirred at room temperature for 16 h. The precipitated compound was collected and washed with water (3×15 ml) and dried to give 4.9 g of 1,3-diphenyl-2-propanone oxime.

Workup

  1. customThe precipitated compound was collected
  2. washwashed with water (3×15 ml)
  3. customdried

Sources & evidence

ORD record
ord-22626a31a2e54b21a199df0d2802c9ce
Source dataset
uspto-grants-1997_03
Patent number
US05608069

Reaction notes

Loading…