Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
D-Alanine → DOTA biotin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | D-Alanine | HCID 71080 | — |
| 반응물 | N-Hydroxysuccinimide | HCID 80170 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 반응물 | Biotinyl-d-alanine | HCID 22863182 | — |
| 반응물 | DOTA aniline | HCID 131719895 | — |
| 생성물 | DOTA biotin | HCID 87364501 | — |
반응 단계
The D-alanine-linked conjugate was prepared by first coupling D-alanine (Sigma Chemical Co.) to biotin-NHS ester. The resultant biotinyl-D-alanine was then activated with 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide hydrochloride (EDCI) and N-hydroxysuccinimide (NHS). This NHS ester was reacted in situ with DOTA-aniline to give the desired product which was purified by preparative HPLC.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05608060 |
| 출처 데이터셋 | uspto-grants-1997_03 |
| ORD ID | ord-855fa1f2efa64cb4a6f68cb45ccf725e |
| 출처 메모 | uspto-grants-1997_03 |