Ammonia → 4-Butoxybenzenesulfonamide

HRID 975323Notes

Reaction equation

HRID 975323 reaction equation
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12](Cl)(=[O:14])=[O:13])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4].[NH3:16]>>[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([NH2:16])(=[O:14])=[O:13])=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 5179904-Butoxybenzenesulfonyl Chloride

Product 1

HCID 20491874-Butoxybenzenesulfonamide

Conditions

Temperature
20 °C

Procedure

100 ml of methanolic ammonia solution are added dropwise with ice-cooling to 10 g of 4-n-butoxybenzenesulfonyl chloride. After stirring at 20° C. for 1/2 hour, the mixture is concentrated, the residue is treated with water, acidified to pH 1-2 and filtered off with suction, M.p. 99°-101° C.

Workup

  1. concentrationthe mixture is concentrated
  2. additionthe residue is treated with water
  3. filtrationfiltered off with suction, M.p. 99°-101° C.

Sources & evidence

ORD record
ord-ea7f2df42eab4d41b5ec6bdc7486d836
Source dataset
uspto-grants-1997_03
Patent number
US05607954

Reaction notes

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